Icebol (Turanabol)

Indications:

Protein synthesis perturbation, different genesis of cachexia, trauma, extensive burns after irradiation, infectious diseases, muscular dystrophy, osteoporosis, negative nitrogen balance corticosteroid therapy, aplastic anemia and hypo.

Turanabol itself includes anabolic effects, can be used as an adjunctive therapy in cases of protein catabolism with negative nitrogen balance (deficiency , excessive consumption or loss of protein) in the elderly with denutrition status and cachexia, in asthenia, cachexia different origin in combustion vast and bedsores , after surgery, infections and major trauma, osteoporosis, continuous use of glucocorticoids, and aplastic anemia; hemolytic anemia, chronic anemia, chronic renal failure, anemia caused by tumors, lymphomas and leukemia, idiopathic thrombocytopenia, muscle atrophy in patients with AIDS in pediatric practice in case of increasing retention, anorexia (lack of appetite), weight reduction, etc.

Contra- indications:

Turanabol is not indicated if the person meets hypersensitivity to the drug, adenoma of prostate cancer, male breast cancer, breast carcinoma in women with hypercalcemia, ovarian cancer, CPI, severe atherosclerosis, nephritis, nephrotic syndrome, renal and hepatic dysfunction, acute and chronic prostatitis, pregnancy, lactation period, until sexual maturation.

Administration:

The treatment with Turanabol is additive and cannot replace the basic treatment. The therapy period with Turanabol lasts according to the patient’s reaction and the appearance of possible side effects.

Turanabol optimal dose for adults is 20-50 mg per day. The Turanabol therapy period lasts for 2-6 weeks.

Medical action:

Turanabol is an androgenic and anabolic drug, that gets into the cell membranes and binds with cytoplasmic receptors and the formed bundle is led into the nucleus where it works on specific nuclear receptors. The bundle binds to DNA and acts as a transcription factor that causes the synthesis of RNA and different proteins.

Turanabol has an anabolic effect which is especially seen in striated muscles and bones, and other tissues with high division (bone marrow, mucous etc.). Turanabol causes increased muscle mass and growth rate. Provides calcium fixation in bones, because of increased matrix protein formation and / or reduction in parathyroid hormone responsiveness of bone tissue. An important factor lies in achieving anabolic metabolic changes: a positive nitrogen balance (nitrogen retention), high protein synthesis, decreased catabolism of amino acids, phosphorus and potassium retention. The drug activates hematopoiesis, especially erythropoiesis (erythropoietin formation increases) and favors leucopoiesis and platelet formation.

Precautions:

In case of possible administration of this drug patents must be informed about possible side effects, and they should contact with their doctor immediately if they take place. If signs of virilization take place (deepening of the voice, hirsutism, acne, clitoromegaly) administration should be discontinued to avoid unavoidable changes.

This medicine can cause suppression of plasma coagulation factors II, V, VII, X and this asks for careful monitoring, including concomitant use with indirect anticoagulants.

During the therapy, it is necessary to observe liver function parameters (transaminases, alkaline phosphatase, and bilirubin) and lipid (cholesterol and low density lipoproteins). In the old persons, it can be observed an increased incidence of hypertrophy and prostate carcinoma that needs close monitoring.

For children use anabolic drug needs caution because they may accelerate epiphyseal closure, effect that may last for 6 months after suspension. From this cause, it is recommended to contact with specialists about rationality drug using, following radiological bone maturation monitor.

The usage of high doses of anabolic drugs needs frequent determination of hemoglobin and hematocrit due to possible polycythemia.

Side effects:

Liver disorders: cholestatic jaundice, rare hepatocytes with hepatic necrosis, hepatocellular neoplasms. It can change the biochemical parameters: increase the level of bilirubin, alkaline phosphatase, transaminases. Cholestatic jaundice may develop after 6 weeks or more of treatment (home is considered as toxic) and is manifested by hyperbilirubinemia bile stasis in the capillaries and increase alkaline phosphatase content. Prolonged use for many years may increase the frequency of liver tumors.

Endocrine disorders: Turanabol rarer than other anabolic steroids in men can cause reduced spermatogenesis and sexual potency (secondary to decrease gonadotropins and testosterone secretion with testicular atrophy and oligospermia) prostate hypertrophy (mainly in elderly patients), epididymitis, chronic priapism. In boys may cause early sexual maturation, frequent erections, increasing risk of growing retention.

Neurological disorders: excitation, insomnia, depression, confusion.

Metabolism : reduced glucose tolerance , increase low-density lipoproteins levels (LDL ) , accelerated phase creatinine, increased level of creatine, swelling due to sodium and water reabsorption, retention of potassium, calcium, phosphorus . In people long attached to the bed can be found hypercalcemia

Miscellaneous: during puberty may close early epiphyseal areas with increased retention.

Over dosage:

Overdose situations are not met.